Hydrocortisone Tertiary-Butylacetate for Intra-Articular Therapy in Rheumatic Diseases

Hydrocortisone tertiary-butylacetate for intra-articular therapy in rheumatic diseases.

In arthritic individuals who have only one or two peripheral joints causing difficulty, it would seem advisable to treat these joints locally by direct intraarticular injection of medication in an effort to decrease the incidence and severity of toxicity associated with systemic therapy. The first very effective anti-rheumatic preparation for intraarticular injection was hydrocortisone acetate ...

Intra-articular therapy in osteo-arthritis; comparison of hydrocortisone acetate and hydrocortisone tertiary-butylacetate.

The intra-articular injection of hydrocortisone acetate is commonly used in the treatment of osteoarthritis, although its action in this disease has received less careful study than in rheumatoid arthritis. In 1955 a less soluble ester, hydrocortisone tertiary-butylacetate (TBA) was developed for intraarticular therapy with the claim that its effects were more pronounced and of longer duration ...

Intra-articular therapy in arthritis with special reference to hydrocortisone.

Intra-articular hydrocortisone in osteo-arthrosis.

There is no doubt about the value of intraarticular hydrocortisone in the treatment of rheumatoid arthritis. Controversy has arisen however about its value in the treatment of osteo-arthrosis. Hollander, who introduced this useful form of therapy, has remained an advocate of its use in both conditions (Hollander, 1966). Because of the lack of distinction between the response in patients with rh...

Intra-articular therapy in osteoarthritis.

The medical literature was reviewed from 1968-2002 using Medline and the key words "intra-articular" and "osteoarthritis" to determine the various intra-articular therapies used in the treatment of osteoarthritis. Corticosteroids and hyaluronic acid are the most frequently used intra-articular therapies in osteoarthritis. Other intra-articular substances such as orgotein, radiation synovectomy,...